Exendin-4 Improves β-Cell Function in Autophagy-Deficient β-Cells
نویسندگان
چکیده
منابع مشابه
Exendin-4 Stimulation of Cyclin A2 in β-Cell Proliferation
OBJECTIVE Beta-cell proliferation is an important mechanism underlying beta-cell mass adaptation to metabolic demands. We have examined effects, in particular those mediated through intracellular cAMP signaling, of the incretin hormone analog exendin-4 on cell cycle regulation in beta-cells. RESEARCH DESIGN AND METHODS Changes in islet protein levels of cyclins and of two critical cell cycle ...
متن کاملGastric bypass improves β-cell function and increases β-cell mass in a porcine model.
The most frequently used and effective treatment for morbid obesity is Roux-en-Y gastric bypass surgery (RYGB), which results in rapid remission of type 2 diabetes in most cases. To what extent this is accounted for by weight loss or other factors remains elusive. To gain insight into these mechanisms, we investigated the effects of RYGB on β-cell function and β-cell mass in the pig, a species ...
متن کاملPhosphodiesterase 5 Inhibition Improves β-Cell Function in Metabolic Syndrome
OBJECTIVE This study tested the hypothesis that phosphodiesterase 5 inhibition alone or in combination with ACE inhibition improves glucose homeostasis and fibrinolysis in individuals with metabolic syndrome. RESEARCH DESIGN AND METHODS Insulin sensitivity, beta-cell function, and fibrinolytic parameters were measured in 18 adults with metabolic syndrome on 4 separate days after a randomized,...
متن کاملExendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation.
The Wnt-signaling pathway regulates β-cell functions. It is not known how the expression of endogenous Wnt-signaling molecules is regulated in β-cells. Therefore, we investigated the effect of antidiabetic drugs and glucose on the expression of Wnt-signaling molecules in β-cells. Primary islets were isolated and cultured. The expression of Wnt-signaling molecules (Wnt-4, Wnt-10b, Frizzled-4, LR...
متن کاملExendin-4 Inhibits Hepatic Lipogenesis by Increasing β-Catenin Signaling
The aim of this study is to investigate whether the beneficial effect of exendin-4 on hepatic steatosis is mediated by β-catenin signaling. After the HepG2 human hepatoma cells were treated with PA for 24 hours, total triglycerides levels were increased in a dose-dependent manner, and the expression levels of perilipin family members were upregulated in cells treated with 400 μM PA. For our in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrinology
سال: 2013
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2013-1578